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What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology.
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Identification of neural oscillations and epileptiform changes in human brain organoids
Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and …
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TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
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Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke
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An incoherent feedforward loop interprets NF$ąppa$B/RelA dynamics to determine TNF-induced necroptosis decisions
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Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics
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A regulatory circuit controlling the dynamics of NFκB cRel transitions B cells from proliferation to plasma cell differentiation
Humoral immunity depends on efficient activation of B cells and their subsequent differentiation into antibody-secreting cells (ASCs). …
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An NFκB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFκB via distinct mechanisms
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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
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Identifying noise sources governing cell-to-cell variability
Phenotypic differences often occur even in clonal cell populations. Many potential sources of such variation have been identified, from …
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