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What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology.
Simon Mitchell
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Identification of neural oscillations and epileptiform changes in human brain organoids
Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and …
Ranmal A. Samarasinghe
,
Osvaldo A. Miranda
,
Jessie E. Buth
,
Simon Mitchell
,
Isabella Ferando
,
Momoko Watanabe
,
Thomas F. Allison
,
Arinnae Kurdian
,
Namie N. Fotion
,
Michael J. Gandal
,
Peyman Golshani
,
Kathrin Plath
,
William E. Lowry
,
Jack M. Parent
,
Istvan Mody
,
Bennett G. Novitch
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DOI
TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
Emma Kennedy
,
Eve Coulter
,
Emma Halliwell
,
Nuria Profitos-Peleja
,
Elisabeth Walsby
,
Barnaby Clark
,
Elizabeth H Phillips
,
Thomas A Burley
,
Simon Mitchell
,
Stephen Devereux
,
others
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Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke
Shahrzad Latifi
,
Simon Mitchell
,
Rouhollah Habibey
,
Fouzhan Hosseini
,
Elissa Donzis
,
Ana Marı́a Estrada-Sánchez
,
H Rezaei Nejad
,
Michael Levine
,
Peyman Golshani
,
S Thomas Carmichael
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An incoherent feedforward loop interprets NF$ąppa$B/RelA dynamics to determine TNF-induced necroptosis decisions
Marie Oliver Metzig
,
Ying Tang
,
Simon Mitchell
,
Brooks Taylor
,
Robert Foreman
,
Roy Wollman
,
Alexander Hoffmann
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Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics
Kim A Ngo
,
Kensei Kishimoto
,
Jeremy Davis-Turak
,
Aditya Pimplaskar
,
Zhang Cheng
,
Roberto Spreafico
,
Emily Y Chen
,
Amy Tam
,
Gourisankar Ghosh
,
Simon Mitchell
,
others
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A regulatory circuit controlling the dynamics of NFκB cRel transitions B cells from proliferation to plasma cell differentiation
Humoral immunity depends on efficient activation of B cells and their subsequent differentiation into antibody-secreting cells (ASCs). …
Koushik Roy*
,
Simon Mitchell
,
Yi Liu
,
Sho Ohta
,
Yu-sheng Lin
,
Marie Oliver Metzig
,
Stephen L Nutt
,
Alexander Hoffmann
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An NFκB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFκB via distinct mechanisms
Simon Mitchell
,
Ellen L Mercado
,
Adewunmi Adelaja
,
Jessica Q Ho
,
Quen J Cheng
,
Gourisankar Ghosh
,
Alexander Hoffmann
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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Simon Mitchell
,
Alexander Hoffmann
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Identifying noise sources governing cell-to-cell variability
Phenotypic differences often occur even in clonal cell populations. Many potential sources of such variation have been identified, from …
Simon Mitchell
,
Alexander Hoffmann
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