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TLR9-dependent migration identifies different Chronic Lymphocytic Leukemia signaling states under BTK inhibition.
B-cell receptor (BCR) inhibitors have transformed chronic lymphocytic leukemia (CLL) therapy, yet many patients show incomplete …
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Exploring the Bone Marrow Microenvironment as a Therapeutic Barrier and Targetable Source of Crosstalk in Acute Myeloid Leukemia
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From Planning to Public Benefit: How Open Data Improves Your Research
Research is increasingly a team sport, with collaborative research having the highest impact (Wuchty et al., 2007). Simultaneously, a …
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Development of a translational strategy for using TIMP-3 to inhibit aggrecanase activity in osteoarthritis
Objective: Therapeutic potential of selective aggrecanase inhibition in osteoarthritis (OA) was previously demonstrated using a variant …
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Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Genetic heterogeneity and co-occurring driver mutations impact clinical outcomes in blood cancers, but predicting the emergent effect …
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Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Integrated transcriptomic analysis reveals immune signatures distinguishing persistent versus resolving outcomes in MRSA bacteremia

Introduction Staphylococcus aureus bacteremia (SAB) is a life-threatening infection particularly involving methicillin-resistant S. …

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Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a common and life-threatening infection that imposes up to …

DOI
Computational modeling of DLBCL predicts response to BH3-mimetics
In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this …
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Computational modeling of DLBCL predicts response to BH3-mimetics
NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
Introduction. Improving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. …
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NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
NF-kB and the CLL microenvironment
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western world. Despite the positive clinical effects …
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NF-kB and the CLL microenvironment