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Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Genetic heterogeneity and co-occurring driver mutations impact clinical outcomes in blood cancers, but predicting the emergent effect …
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Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Computational modeling of DLBCL predicts response to BH3-mimetics
In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this …
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Computational modeling of DLBCL predicts response to BH3-mimetics
NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
Introduction. Improving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. …
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NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
NF-kB and the CLL microenvironment
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western world. Despite the positive clinical effects …
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NF-kB and the CLL microenvironment
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous cell types, including the inflammatory …
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The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology.
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Identification of neural oscillations and epileptiform changes in human brain organoids
Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and …
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TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
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Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke
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An incoherent feedforward loop interprets NF$ąppa$B/RelA dynamics to determine TNF-induced necroptosis decisions
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