Welcome to the Mitchell Lab

At Brighton and Sussex Medical School, The University of Sussex

We’re tackling cancer with systems biology, in the beautiful city of Brighton, UK.

Meet the team

What we do

Our interdisciplinary approach aims to bring systems biology approaches to the clinic.


to represent cell signaling


to simulate disease


to test predictions


to improve treatments


Therapeutic targeting of refractory/relapsed diffuse large B-cell lymphoma through systems biology

This project is funded by A UKRI Future Leaders Fellowship. We aim to simulate the emergence of relapsed refractory disease during treatment and find therapeutic targets to tackle and prevent refractory/relapsed diffuse large B-cell lymphoma (RR-DLBCL).

A Systems Biology Approach to Tailoring Therapy for Diffuse Large B-Cell Lymphoma

This work is funded by Leukaemia UK and aims to model mutations that give rise to DLBCL in order to identify new targets to treat the disease.

NF-κB Signalling dynamics in health and disease

We are interested in studying NF-κB signalling and cross-talk in health and disease using systems biology. We study how NF-κB signaling dynamics in immune responses control a healthy immune response and how misregulation of NF-κB in cancer results in disease phenotypes.

Meet the Team

Principal Investigator


Simon Mitchell

Senior Lecturer in Cancer Research

Postdoctoral Researchers


Eleanor Jayawant

Postdoctoral Researcher


Ielyaas Cloete

Postdoctoral Researcher


Richard Norris

Postdoctoral Researcher

PhD Students


Arran Pack

PhD Student



Gemma Hamilton


Recent Publications

Quickly discover relevant content by filtering publications.
(2021). TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target. Blood.


(2020). Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke. Cerebral Cortex.


(2020). Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell reports.

(2020). An incoherent feedforward loop interprets NF$ąppa$B/RelA dynamics to determine TNF-induced necroptosis decisions. Molecular Systems Biology.



  • Medical Research Building, University of Sussex, Falmer, East Sussex, BN1 9PX
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