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A regulatory circuit controlling the dynamics of NFκB cRel transitions B cells from proliferation to plasma cell differentiation
Humoral immunity depends on efficient activation of B cells and their subsequent differentiation into antibody-secreting cells (ASCs). …
Koushik Roy*
,
Simon Mitchell
,
Yi Liu
,
Sho Ohta
,
Yu-sheng Lin
,
Marie Oliver Metzig
,
Stephen L Nutt
,
Alexander Hoffmann
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An NFκB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFκB via distinct mechanisms
Simon Mitchell
,
Ellen L Mercado
,
Adewunmi Adelaja
,
Jessica Q Ho
,
Quen J Cheng
,
Gourisankar Ghosh
,
Alexander Hoffmann
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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Simon Mitchell
,
Alexander Hoffmann
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Identifying noise sources governing cell-to-cell variability
Phenotypic differences often occur even in clonal cell populations. Many potential sources of such variation have been identified, from …
Simon Mitchell
,
Alexander Hoffmann
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Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation
Rapid antibody production in response to invading pathogens requires the dramatic expansion of pathogen-derived antigen-specific B …
Simon Mitchell
,
Koushik Roy*
,
Thomas A Zangle
,
Alexander Hoffmann
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Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse
Kyu-Hyeon Yeom
,
Simon Mitchell
,
Anthony J Linares
,
Sika Zheng
,
Chia-Ho Lin
,
Xiao-Jun Wang
,
Alexander Hoffmann
,
Douglas L Black
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Signaling via the NF$ąppa$B system
Simon Mitchell
,
Jesse Vargas
,
Alexander Hoffmann
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Training the 21st century immunologist
Roberto Spreafico
,
Simon Mitchell
,
Alexander Hoffmann
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A computational model of liver iron metabolism
Simon Mitchell
,
Pedro Mendes
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