A Systems Biology Approach to Tailoring Therapy for Diffuse Large B-Cell Lymphoma
Last updated on 9 Sep 2020
This work is funded by Leukaemia UK and aims to model mutations that give rise to DLBCL in order to identify new targets to treat the disease.
In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this …
Introduction. Improving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. …
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western world. Despite the positive clinical effects …
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous cell types, including the inflammatory …
B-cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of …
Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia
Simon Mitchell received the Emerging Impact Award (any career stage), recognising the team’s efforts lay the foundation for personalised medicine in blood cancer using systems biology. Announced during Sussex Research Impact Awards 2023, the award is designed to recognise efforts to prepare and progress the fundamentals important for developing impact.
19 Jul 2023 12:00 AM University of Sussex
The Sussex ECR Dragons’ Den was a competative mutli-round process that saw talented early career reseachers from across the University of Sussex make their pitch for why they should receive research funding to kick start their impactful ideas.
6 Jul 2023 University of Sussex
Leukaemia UK have written an article entitled: “Leukaemia UK research paves the way for personalised lymphoma treatment” highlighting our recent publication successes. Read the full article here.
22 Jun 2023 12:00 AM University of Sussex
Two papers published within 4 days of each other. One in Frontiers in Oncology, lead by Eleanor Jayawant and in NPJ Systems Biology and Applications lead by Ielyaas Cloete. Check out the links above to each paper, or see all of our publications here.
6 Jun 2023 12:00 AM University of Sussex and BSMS
In “The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts” we answer how a highly conserved system can do very different things in different contexts. Congratulations to Arran for his first publiction in the Mitchell lab, as this paper includes a part of his PhD thesis.
16 Mar 2023 1:59 PM
Dr Mitchell will deliver a seminar on using systems biology approaches to understanding B cell fate decisions in health and lymphoma.
25 Jan 2023 4:00 PM Osaka
We have had two projects accepted for talks and two projects accepted for posters at the 21st International Conference on Systems Biology.
8 Oct 2022 — 12 Oct 2022 Berlin
LyMIT 2022 attracts international speakers and audience.
6 Sep 2022 8:30 AM — 5:00 PM University of Sussex
We are excited to share that the Mitchell Lab have had two abstracts accepted for the European Haematology Associations annual congress, EHA2022, June 9th-12th 2022.
27 Apr 2022 — 12 Jun 2022 Vienna
The Mitchell group are participating the European School of Haematology’s 6th Translational Research Conference on Lymphoid Malignancies (ESH Lymphoid 2021) (Oct 14-17 2021). A number of our members presenting research updates, which are available to view now!
14 Oct 2021 5:07 PM
The entire Mitchell group will be participating in SMB 2021 (June 13-17, 2021) with a number of members presenting research updates. Ielyaas Cloete will present his progress in simulating apoptotic signaling networks to enable better understanding their role in B-Cell lymphoma.
20 Oct 2020 5:07 PM
Simon has been invited to present at the European Haematology Associations annual congress, June 9th-17th 2021. Simon will present his progress in understanding diffuse large B-cell lymphoma through systems biology. His presentation “A SYSTEMS BIOLOGY APPROACH TO DLBCL PREDICTS EMERGENT PHENOTYPES FROM MOLECULAR DYSREGULATION AND IDENTIFIES DISTINCT ROLES FOR NF-KB SUBUNITS CREL AND RELA.
20 Oct 2020 5:07 PM