Simon Mitchell

Latest

TLR9-dependent migration identifies different Chronic Lymphocytic Leukemia signaling states under BTK inhibition.
Exploring the Bone Marrow Microenvironment as a Therapeutic Barrier and Targetable Source of Crosstalk in Acute Myeloid Leukemia
From Planning to Public Benefit: How Open Data Improves Your Research
Hox Activity Levels Governs the Evolution of Homologous Behaviors.
Applying computational modelling to a high-risk multiple myeloma data set to create novel risk stratification groupings
Development of a translational strategy for using TIMP-3 to inhibit aggrecanase activity in osteoarthritis
Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL
Computational modelling of aggressive B-cell lymphoma
Design, synthesis and evaluation of Pyrrolobenzodiazepine (PBD)-based PROTAC conjugates for the selective degradation of the NF-κB RelA/p65 subunit
A Systems Biology Approach of Quantifying Signal Transduction to B-Cell Proliferation and Differentiation
Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs
Computational modeling of DLBCL predicts response to BH3-mimetics
NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
NF-kB and the CLL microenvironment
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
Mitchell Lab Alumni
Dissecting the Impact of Bromodomain Inhibitors on the IRF4-MYC Oncogenic Axis in Multiple Myeloma
Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia
Targeting the non-canonical NF-κB pathway in chronic lymphocytic leukemia and multiple myeloma
What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology.
Identification of neural oscillations and epileptiform changes in human brain organoids
Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia
TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke
Machine learning for determining accurate outcomes in criminal trials
An incoherent feedforward loop interprets NF$ąppa$B/RelA dynamics to determine TNF-induced necroptosis decisions
Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics
Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients
A regulatory circuit controlling the dynamics of NFκB cRel transitions B cells from proliferation to plasma cell differentiation
An NFκB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFκB via distinct mechanisms
Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Protective immunity in recurrent <i>Staphylococcus aureus</i> infection reflects localized immune signatures and macrophage-conferred memory
Deriving Quantitative Cell Biological Information from Dye-Dilution Lymphocyte Proliferation Experiments
Identifying noise sources governing cell-to-cell variability
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation
Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse
COMPUTATIONAL MODELLING OF IRON TRANSPORT BETWEEN BLOOD CIRCULATION, BRAIN, AND DOPAMINERGIC NEURONS OF THE SUBSTANTIA NIGRA
Signaling via the NF$ąppa$B system
Studying NF-$ąppa$B signaling with mathematical models
Training the 21st century immunologist
A computational model of liver iron metabolism