Simon Mitchell

Latest

Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Computational modeling of DLBCL predicts response to BH3-mimetics
NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
NF-kB and the CLL microenvironment
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
Mitchell Lab Alumni
Dissecting the Impact of Bromodomain Inhibitors on the IRF4-MYC Oncogenic Axis in Multiple Myeloma
Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia
Targeting the non-canonical NF-κB pathway in chronic lymphocytic leukemia and multiple myeloma
What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology.
Identification of neural oscillations and epileptiform changes in human brain organoids
TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke
An incoherent feedforward loop interprets NF$ąppa$B/RelA dynamics to determine TNF-induced necroptosis decisions
Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics
A regulatory circuit controlling the dynamics of NFκB cRel transitions B cells from proliferation to plasma cell differentiation
An NFκB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFκB via distinct mechanisms
Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Deriving Quantitative Cell Biological Information from Dye-Dilution Lymphocyte Proliferation Experiments
Identifying noise sources governing cell-to-cell variability
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation
Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse
COMPUTATIONAL MODELLING OF IRON TRANSPORT BETWEEN BLOOD CIRCULATION, BRAIN, AND DOPAMINERGIC NEURONS OF THE SUBSTANTIA NIGRA
Signaling via the NF$ąppa$B system
Studying NF-$ąppa$B signaling with mathematical models
Training the 21st century immunologist
A computational model of liver iron metabolism