Therapeutic targeting of refractory/relapsed diffuse large B-cell lymphoma through systems biology

This project is funded by A UKRI Future Leaders Fellowship. We aim to simulate the emergence of relapsed refractory disease during treatment and find therapeutic targets to tackle and prevent refractory/relapsed diffuse large B-cell lymphoma (RR-DLBCL).

A Systems Biology Approach to Tailoring Therapy for Diffuse Large B-Cell Lymphoma

This work is funded by Leukaemia UK and aims to model mutations that give rise to DLBCL in order to identify new targets to treat the disease.

NF-κB Signalling dynamics in health and disease

We are interested in studying NF-κB signalling and cross-talk in health and disease using systems biology. We study how NF-κB signaling dynamics in immune responses control a healthy immune response and how misregulation of NF-κB in cancer results in disease phenotypes.