Abstract
The paper combines in vitro, in vivo, and in silico systems biology to understand how BH3-mimetic sensitivity is controlled in the lymphoma microenvironment.
Date
16 Aug 2025 5:07 PM
Location
Cell Death & Disease
The paper shows that inhibition of NFκB can overcome tumour microenvironment-mediated drug resistance in DLBCL, and re-sensitize lymphoma cells to BH3-mimetics.
Simon Mitchell
Professor in Cancer Research
My primary research focus is in understanding how intracellular, molecular signalling networks control immune cell fate, and how misregulation of these molecular networks leads to haematological malignancies. My combination of immunology and haematological training lead to a particular interest in B-cell lymphomas.