Extending personalised modelling towards clinical use in multiple malignancies

Last updated on 9 Mar 2025

This work is funded by a UKRI Future Leaders Fellowship Renewal and aims to extend our impact beyond Diffuse Large B Cell Lymphoma to related malignancies such as Chronic Lymphocytic Leukaemia (CLL), multiple myeloma, and breast cancer.

Multi-malignancy

Publications

A Novel In Vitro Model of the Bone Marrow Microenvironment in Acute Myeloid Leukemia Identifies CD44 and Focal Adhesion Kinase as Therapeutic Targets to Reverse Cell Adhesion-Mediated Drug Resistance
Background/Objectives: Acute myeloid leukemia (AML) is an aggressive neoplasm. Although most patients respond to induction therapy, …
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NF-kB and the CLL microenvironment
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western world. Despite the positive clinical effects …
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NF-kB and the CLL microenvironment
Dissecting the Impact of Bromodomain Inhibitors on the IRF4-MYC Oncogenic Axis in Multiple Myeloma
B-cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of …
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Dissecting the Impact of Bromodomain Inhibitors on the IRF4-MYC Oncogenic Axis in Multiple Myeloma
Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia
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Targeting the non-canonical NF-κB pathway in chronic lymphocytic leukemia and multiple myeloma
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TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
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